Download e-book for kindle: 2014-2015 Basic and Clinical Science Course (BCSC): Section by American Academy of Ophthalmology, Ramana S. Moorthy MD

By American Academy of Ophthalmology, Ramana S. Moorthy MD

ISBN-10: 161525563X

ISBN-13: 9781615255634

Starts off with an summary of immune-mediated eye affliction, summarizing easy immunologic thoughts, ocular immune responses and specified issues in ocular immunology. Discusses the scientific method of uveitis and reports noninfectious (autoimmune) and infectious kinds of uveitis, with an increased part on viral uveitis and new fabric on infectious and noninfectious scleritis.

Enhanced detection of infectious brokers by way of immunologic and genetic tools and biologic therapeutics are certain. additionally covers endophthalmitis, masquerade syndromes, issues of uveitis and ocular points of AIDS.

Upon final touch of part nine, readers can be capable to:

Identify normal and particular pathophysiologic approaches that impact the constitution and serve as of the uvea, lens, intraocular cavities, retina, and different tissues in acute and persistent intraocular inflammation
Differentiate and establish infectious and noninfectious uveitic entities
Choose applicable exam options and correct ancillary stories according to no matter if an infectious or noninfectious reason is suspected

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Extra info for 2014-2015 Basic and Clinical Science Course (BCSC): Section 9: Intraocular Inflammation and Uvetis

Sample text

CDS T lymphocytes include natural killer T cells and regulatory T cells. Class I molecules are present on almost all nucleated cells. In general, class I APCs are best for processing peptide antigens that have been synthesized by the host cell itself, including most tumor peptides or viral peptides after host cell invasion. MHC class II molecules (ie, HLA-DR, -DP, and-DQ) serve as the antigen-presenting platform for CD4, or helper, T lymphocytes (Fig 2-3). All APCs for CD4 T lymphocytes must express the MHC class II molecule, and the antigen receptor on the helper T lymphocyte can recognize peptide antigens only if they are presented with class II molecules simultaneously.

In contrast with :ostaglru,dins, /eukotrienes probably contribute significantly to inflammatory infiltra~uon. One of the best characterized i leukotriene B4, a potent chemotactic factor that also ·auses Jyso mal enzyme relea e and reactive oxygen radical production by granulocytes. Some leukotrienes may have 1000 times the effect of histamine on vascular permeability. in, i a potent stimulator of superoxide anion. 111 Plate/et-activating factors Platelet-activating factors are a family of phospholipid-derived mediators that appear to be important stimuli in the early stage of inflammation.

For example, trauma or toxins interacting directly with nonimmune ocular parenchymal cells, especially iris or ciliary body epithelium, retinal pigment epithelium, retinal Muller cells, or corneal or conjunctival epithelium, can result in a wide range of mediator, cytokine, and eicosanoid synthesis, and this mechanism should be considered a form of innate im munity. Thus, phagocytosis of staphylococci by corneal epithelium, microtrauma to the ocular surface epithelium by contact lenses, chafing of iris or ciliary epithelium by an intraocular lens (IOL), or laser treatment of the retina can stimulate ocular cells to produce mediators that assist in the recruitment of innate effector cells such as neutrophils or macrophages.

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2014-2015 Basic and Clinical Science Course (BCSC): Section 9: Intraocular Inflammation and Uvetis by American Academy of Ophthalmology, Ramana S. Moorthy MD


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