Download e-book for kindle: Acute and Long-Term Side-Effects of Radiotherapy: Biological by J. W. Hopewell, W. Calvo, R. Jaenke, H. S. Reinhold, M. E.

By J. W. Hopewell, W. Calvo, R. Jaenke, H. S. Reinhold, M. E. C. Robbins, E. M. Whitehouse (auth.), PD Dr. Wolfgang Hinkelbein, Dr. Gregor Bruggmoser, Prof. Dr. Hermann Frommhold, Prof. Dr. Michael Wannenmacher (eds.)

ISBN-10: 3642848923

ISBN-13: 9783642848926

ISBN-10: 364284894X

ISBN-13: 9783642848940

Biologists and radiotherapists current their experimental paintings and medical information within the box of radiation accidents of ordinary tissues and organs. specific regard is payed to the relevance of organic mechanisms in medical occasions. ideas of radiation harm and mixed therapy toxicity in radio-chemotherapy are being defined. the most issues mentioned are the significance of microvasculature, time, doseand fractionation and components enhancing scientific radioresponse for early andlate radiation results. Tissues and organs thought of during this quantity are mucosa and epidermis, lung and middle, bladder and muscle, CNS and eye. exact difficulties of pediatric radiotherapy, TBI, IORT and moment malignacies also are mentioned.

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Extra resources for Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance

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Accelerated cell turnover has been reported in bladder, lung, spinal cord, and kidney (reviewed by Thames and Hendry 1987; Soranson 1990), which may increase somewhat these speculative calculated values of Gy/day. Regarding repair, there is indeed evidence for less and slower repair of high-LET lesions within single cells. The method of premature chromosome condensation (PCC) has been used to reveal chromosome lesions in the interphase nucleus (Goodwin et al. 1989; Bedford and Goodhead 1989). For the same initial number of chromatin breaks, 90% rejoined by 7 h after Xrays compared with only 50% after neon ions, with far fewer ring PCC aberrations being formed (Goodwin et al.

These studies illustrate that if the acute toxicity of radiation therapy is increased to such a degree that interruptions of the treatment become necessary, a reduced probability of local tumor control is expected for affected patients. If noxious factors are the cause of these increased acute reactions, abstinence from such factors is expected to be effective in further improving the results of radiation treatment. Unfortunately this situation is much more complex in the case of increased late normal tissue damage, for example after irradiation of organs which were already damaged before treatment.

An explanation is that this phenomenon reflects increasing radioresistance as X-ray dose is increased from zero to about 1 Gy, due to the induction of repair systems or other radioprotective mechanisms. The Response of Tissues to Very Low Doses per Fraction 39 Acknowledgments. This work was supported entirely by the Cancer Research Campaign of the UK. We are grateful to Dr. S. Parkins for supplying us with the data on which Fig. 4 is based. References Beck-Bornholdt HP, Maurer T, Becker S, Omniczynski M, Vogler H, Wurschmidt F (1989) Radiotherapy of the rhabdomyosarcoma R1H of the rat: hyperfractionation - 126 fractions applied within 6 weeks.

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Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance by J. W. Hopewell, W. Calvo, R. Jaenke, H. S. Reinhold, M. E. C. Robbins, E. M. Whitehouse (auth.), PD Dr. Wolfgang Hinkelbein, Dr. Gregor Bruggmoser, Prof. Dr. Hermann Frommhold, Prof. Dr. Michael Wannenmacher (eds.)


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