By R. Millis
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Extra info for Advances in Electrocardiograms - Clinical Applns.
It was assumed that the suppression of PVCs with antiarrhythmic drugs would be beneficial but the disappointing results of the CAST trials (CAST Investigators, 1989, 1992) negated the causal role theory of PVCs. In fact, the negating of the “PVC hypothesis” by the CAST results is a classic example of why hypothetical The Prevalence and Prognostic Value of Rest Premature Ventricular Contractions 35 mechanisms cannot replace the evidence based approach. Partly due to these results, PVCs are generally ignored on a routine ECG.
These characteristics included presence of multiple PVCs on a single 10-sec ECG, presence of couplets or salvos (≥3 consecutive PVCs), presence of bigeminal or trigeminal rhythm, and presence of multiform PVC morphologies. For the purposes of this study, complex PVCs were defined as repetitive PVCs (≥2 consecutive) and multiform morphologies. Non-sustained ventricular tachycardia was rarely documented on these short recordings and the few short runs of 3 or more consecutive beats were not analyzed separately.
Risk factors associated with the QT interval prolongation in subjects with and without type 2 diabetes. 75) (Table 4). Antihypertensive therapy had a negative effect in QTc prolongation. 032). (Data not shown) 4. Discussion The methods used in the Mexico City Diabetes Study meet the accepted international criteria in terms of study protocol, diagnostic algorithms, and particularly electrocardiographic interpretations.  The ECGs were interpreted without disclosure of clinical or laboratory data, in a reference center recognized as a gold standard for this procedure.
Advances in Electrocardiograms - Clinical Applns. by R. Millis